Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer
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Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer
Cell-intrinsic metabolic reprogramming is a hallmark of cancer that provides anabolic support to cell proliferation. How reprogramming influences tumor heterogeneity or drug sensitivities is not well understood. Here, we report a self-organizing spatial pattern of glycolysis in xenograft colon tumors where pyruvate dehydrogenase kinase (PDK1), a negative regulator of oxidative phosphorylation, ...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2017
ISSN: 1744-4292,1744-4292
DOI: 10.15252/msb.20167386